{"id":28275,"date":"2015-08-12T12:04:41","date_gmt":"2015-08-12T10:04:41","guid":{"rendered":"https:\/\/ocasapiens-dweb.blogautore.repubblica.it\/?p=28275"},"modified":"2021-10-17T22:03:40","modified_gmt":"2021-10-17T20:03:40","slug":"damn-lies-andor-statistics-cont","status":"publish","type":"post","link":"https:\/\/archivio.ocasapiens.org\/index.php\/2015\/08\/12\/damn-lies-andor-statistics-cont\/","title":{"rendered":"Damn lies and\/or statistics, cont."},"content":{"rendered":"<p>Mi ripeto, lo so, sar\u00e0 la canicola, l&#8217;Alzheimer, l&#8217;et\u00e0 fate voi, ma nella ricerca biomed &#8211; quella che citavo in &#8220;University of B&#8230;&#8221; inclusa &#8211; dovrebbero essere obbligatorie la lettura di &#8220;<a href=\"http:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.0020124\" target=\"_blank\" rel=\"noopener\">Why most published research findings are false<\/a>&#8221; e due giorni di full immersion negli inganni della statistica.<\/p>\n<p>Cos\u00ec il chirurgo <a href=\"https:\/\/media.licdn.com\/mpr\/mpr\/shrinknp_400_400\/p\/4\/005\/082\/018\/094495f.jpg\" target=\"_blank\" rel=\"noopener\">Giovanni Domenico Tebala\u00a0<\/a>di <a href=\"http:\/\/www.abcsalute.it\/medici\/gastroenterologia\/lazio\/roma\/roma\/dr-tebala-giovanni-domenico-chirurgo-generale-european-hospital-.html\" target=\"_blank\" rel=\"noopener\">Roma<\/a> e dell&#8217;<a href=\"https:\/\/www.facs.org\/profile\/55375052\" target=\"_blank\" rel=\"noopener\">Isola di Man<\/a>, evitava di chiedersi su <em>Medical Hypotheses <\/em>(rivista a volte\u00a0<a href=\"http:\/\/neurocritic.blogspot.it\/2008\/09\/more-truly-truly-outrageous-medical.html\" target=\"_blank\" rel=\"noopener\">inaffidabile<\/a>),<\/p>\n<p style=\"text-align: center;\"><em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26194725\" target=\"_blank\" rel=\"noopener\">What is the future of biomedical research?<\/a>\u00a0<\/em><\/p>\n<p>e di rispondere pubblicamente:<\/p>\n<p><em>Statistical analysis showed an exponential increase of synthetic studies with respect to randomized trials. The ratio between RCTs and synthetic studies is quickly decreasing&#8230;<\/em><\/p>\n<p>A suo avviso, il rapporto \u00e8 di 1 studio sintetico per 3 trial clinici, e ne deriva una tendenza pericolosa. Pur di gonfiarsi il cv e il citation index, i ricercatori sarebbero sempre pi\u00f9 tentati di sfruttare il lavoro altrui:<\/p>\n<p><em>Randomized controlled trials require hard work and financial commitment, whereas meta-analyses and systematic reviews can be relatively easy to perform and often get published in high impact journals. Many researchers might decide to devote themselves to the latter approach.<\/em><\/p>\n<p>Forse, ma la sua &#8220;statistical analysis&#8221; \u00e8 &#8220;sub-optimal&#8221;. Se chiedeva a\u00a0<a href=\"http:\/\/www.ioe.ac.uk\/staff\/FFCH_22.html\" target=\"_blank\" rel=\"noopener\">Sergio Graziosi<\/a> dell&#8217;EPPI-UCL, <strong><a href=\"http:\/\/blogs.discovermagazine.com\/neuroskeptic\/2015\/08\/10\/are-there-too-many-meta-analyses\/#comment-2187069414\" target=\"_blank\" rel=\"noopener\">otteneva <\/a><\/strong>2.091 rassegne per 93.036 trial clinici, un rapporto un tantino diverso&#8230; Tra l&#8217;altro,\u00a0l&#8217;aumento costante di dati originali significa che n\u00e9 lui n\u00e9 altri hanno il tempo di confrontarli e di valutarne affidabilit\u00e0 e rilevanza. Ne vengono a conoscenza grazie a\u00a0<a href=\"http:\/\/www.systematicreviewsjournal.com\/content\/2\/1\/74\" target=\"_blank\" rel=\"noopener\">meta-analisi e rassegne<\/a>\u00a0che richiedono metodo e hard work.<\/p>\n<p>\u00a0<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" style=\"line-height: 1.5em;\" src=\"http:\/\/4.bp.blogspot.com\/-kPfw7VBDIC8\/UH7e3XQwSDI\/AAAAAAAAO6E\/Qpllcy9CsgM\/s1600\/-WM_strip_DK_20120416.jpg\" alt=\"\" \/><\/p>\n<p style=\"text-align: center;\"><a href=\"http:\/\/zum-wilden-hirsch.blogspot.it\/\" target=\"_blank\" rel=\"noopener\">fonte<\/a><\/p>\n<p>A proposito, <strong><a href=\"https:\/\/tamino.wordpress.com\/2015\/08\/10\/survival\/\" target=\"_blank\" rel=\"noopener\">Tamino<\/a><\/strong> ha inventato un altro metodo &#8211; <strong><a href=\"https:\/\/tamino.wordpress.com\/2015\/08\/11\/survival-part-ii\/\" target=\"_blank\" rel=\"noopener\">bayesiano<\/a><\/strong>! una concessione inaspettata &#8211; per calcolare la funzione\/<a href=\"https:\/\/it.wikipedia.org\/wiki\/Stimatore_di_Kaplan-Meier\" target=\"_blank\" rel=\"noopener\">stimatore K-M<\/a>\/<a href=\"https:\/\/fr.wikipedia.org\/wiki\/Analyse_de_survie#Fonction_de_survie\" target=\"_blank\" rel=\"noopener\">analisi di sopravvivenza<\/a> (una probabilit\u00e0):<\/p>\n<p><em>which finds application in many fields, most notably medical research (where survival is considered important) and failure testing. I\u2019ve come up with a new way to estimate it from observed data, and most important, what I believe is a much-improved way to estimate confidence limits.<\/em><\/p>\n<p>Caveat:<br \/><em>Of course I could be wrong. And of course it\u2019s possible somebody else already thought of it, and it\u2019s published somewhere I\u2019m not aware of. That\u2019s the way science works. But I have submitted a manuscript for publication, so I should find out before too long. In the meantime, I\u2019ll share it here.<\/em><\/p>\n<p style=\"text-align: center;\">***<\/p>\n<p style=\"text-align: center;\">\u00a0<\/p>\n<p><strong><strong>Il Napoleone di Miami Beach, &#8220;<a href=\"http:\/\/ecx.images-amazon.com\/images\/I\/518OVMCUDJL._SY300_.jpg\" target=\"_blank\" rel=\"noopener\">unfiltered<\/a><\/strong>&#8230;<br \/><\/strong><br \/>Andrea Rossi che chiama un nuovo e-cat &#8220;M.me Curie&#8221; ha cancellato un commento in cui a suo avviso il suo nome da nubile era <a href=\"https:\/\/it.wikipedia.org\/wiki\/Maria_Walewska\">Maria Walewska<\/a> (salvato per i credenti su <a href=\"http:\/\/www.cobraf.com\/showimage.php?image=\/forum\/immagini\/R_123597166_1.jpg\" target=\"_blank\" rel=\"noopener\">Cobraf,)<\/a> ma si \u00e8 dimenticato di cancellare la risposta di <strong><a href=\"http:\/\/www.journal-of-nuclear-physics.com\/?p=885&amp;cpage=9#comment-1108898\" target=\"_blank\" rel=\"noopener\">Alexvs<\/a><\/strong>. Da abbinare a questa (psic)<a href=\"http:\/\/www.e-catworld.com\/2015\/08\/11\/what-exactly-is-the-mme-curie-reactor-a-direct-source-of-electricity\/#comment-2187351048\" target=\"_blank\" rel=\"noopener\">analisi<\/a> su e-cat world:<\/p>\n<p><em>The name has to be a big clue, at least into what Rossi thinks of it via his thought process and symbolism unfiltered from excitement.<\/em><\/p>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mi ripeto, lo so, sar\u00e0 la canicola, l&#8217;Alzheimer, l&#8217;et\u00e0 fate voi, ma nella ricerca biomed &#8211; quella che citavo in &#8220;University of B&#8230;&#8221; inclusa &#8211; dovrebbero essere obbligatorie la lettura di &#8220;Why most published research findings are false&#8221; e due giorni di full immersion negli inganni della statistica. Cos\u00ec il chirurgo Giovanni Domenico Tebala\u00a0di Roma&hellip; <a class=\"more-link\" href=\"https:\/\/archivio.ocasapiens.org\/index.php\/2015\/08\/12\/damn-lies-andor-statistics-cont\/\">Continua a leggere <span class=\"screen-reader-text\">Damn lies and\/or statistics, cont.<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,19,20],"tags":[437,2843,2852,4447,6513],"class_list":["post-28275","post","type-post","status-publish","format-standard","hentry","category-bufala","category-matematica","category-medicina","tag-andrea-rossi","tag-funzione-di-sopravvivenza","tag-fusione-fredda","tag-metodo-bayesiano","tag-statistica","entry"],"_links":{"self":[{"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/posts\/28275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/comments?post=28275"}],"version-history":[{"count":3,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/posts\/28275\/revisions"}],"predecessor-version":[{"id":43250,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/posts\/28275\/revisions\/43250"}],"wp:attachment":[{"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/media?parent=28275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/categories?post=28275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/tags?post=28275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}