{"id":32871,"date":"2017-11-09T13:14:17","date_gmt":"2017-11-09T12:14:17","guid":{"rendered":"https:\/\/ocasapiens-dweb.blogautore.repubblica.it\/?p=32871"},"modified":"2017-11-09T13:14:17","modified_gmt":"2017-11-09T12:14:17","slug":"un-bambino-farfalla-gioca-a-calcio","status":"publish","type":"post","link":"https:\/\/archivio.ocasapiens.org\/index.php\/2017\/11\/09\/un-bambino-farfalla-gioca-a-calcio\/","title":{"rendered":"Un bambino "farfalla" gioca a calcio"},"content":{"rendered":"

Su Nature<\/em>, l’editoriale<\/span><\/a>\u00a0<\/span>e sopratutto l’articolo<\/a>\u00a0del gruppo diretto da Michele De Luca, univ. Modena e Reggio Emilia, spiegano le speranze suscitate dalla correzione di un dei geni che, se difettoso, causa l’epidermolisi bullosa, una malattia atroce<\/a> di cui soffrono circa 500 mila persone.<\/p>\n

\n
In June 2015, a seven-year-old child was admitted to the Burn Unit of the Children\u2019s Hospital, Ruhr-University, Bochum, Germany. He\u00a0carried a homozygous acceptor splice site mutation (C1977-1G> A,\u00a0IVS 14-1G> A) within intron 14 of LAMB3. Since birth, the patient\u00a0had developed blisters all over his body, particularly on his limbs,\u00a0back and flanks. His condition deteriorated severely six weeks\u00a0before admission, owing to infection with Staphylococcus aureus\u00a0and Pseudomonas aeruginosa. Shortly after admission, he suffered\u00a0complete epidermal loss on about 60% of his total body surface area\u00a0(TBSA). During the following weeks, all therapeutic approaches failed\u00a0and the patient\u2019s short-term prognosis was unfavourable.<\/div>\n<\/div>\n

Il comitato etico ha approvato la terapia con un protocollo compassionevole. Quando \u00e8 iniziata, al bambino restava il 20% della pelle. I ricercatori hanno corretto il gene LAMB3 inserendo con un virus quello giusto nella manciata di staminali che gli avevano prelevato, le hanno clonate e cresciute in vitro<\/em> ottenendo lembi di pelle che gli sono stati trapianti in due interventi.
\nLa novit\u00e0 scientifica, scrivono<\/a> Aragona & Blancpain, riguarda le cellule che hanno “amalgamato” la pelle cresciuta in vitro<\/em> con gli strati del derma, il comportamento\u00a0in vivo <\/em>delle staminali insomma, e quindi gli “end-points”, i marcatori con quali misurare i risultati durante un esperimento clinico.<\/p>\n

The patient was discharged in February 2016. His epidermis is\u00a0currently stable and robust, and does not blister, itch, or require\u00a0ointment or medications.\u00a0Ten punch biopsies were taken randomly, 4, 8 and 21 months [circa 20 cicli nei quali l’epidermide si rinnova] after\u00a0grafting. The epidermis had normal morphology and we could not\u00a0detect blisters, erosions or epidermal detachment from the underlying\u00a0dermis.<\/div>\n

Il paziente non \u00e8 mai nominato, le sue foto da \u00e9corch\u00e9 e poi avvolto in un reticolo di cicatrici sono pubblicate con il consenso dei genitori, ma da ieri sera in tutto il mondo si parla di Hassan, il piccolo profugo siriano inseguito dalla morte.\u00a0Rif. Science<\/em><\/a>,\u00a0The Guardian<\/em><\/a>, BBC<\/span><\/a><\/span>, Ed Yong <\/span><\/a><\/span>per The Atlantic, NT Times<\/span><\/a><\/span>,\u00a0Die Zeit<\/span><\/a>, Le Scienze<\/span><\/a><\/span>…<\/em>
\nMichele De Luca \u00e8 quello della terapia Holoclar<\/a> contro una forma di cecit\u00e0, che sostituisce la cornea, per l’epidermolisi bullosa giunturale ha dovuto pazientare a lungo:<\/p>\n

He chose JEB for his first clinical trial, which he registered with the Italian Medicines Agency in 2002. Four years later, he reported his first success, in which he created healthy skin patches from biopsies to replace small areas of sloughed-off skin on the legs of a patient with a form of JEB (F. Mavilio\u00a0et al. Nature Med.\u00a0<\/i>12,\u00a0<\/b>1397\u20131402; 2006<\/a>). New European Commission regulations introduced in 2007 required him to pause the project while he created facilities adhering to \u2018good manufacturing practices\u2019 (GMPs) and a spin-off company to meet the demands for strengthened oversight of cell-based therapies.<\/p>\n

***<\/p>\n

In mezzo ad altre foto che vedono su uno schermo, le pecore riconoscono di pi\u00f9 quella di Emma Watson, scrivono<\/span><\/a><\/span> Franziska Knolle et al. su Royal Society Open Science<\/em>:<\/p>\n

\"Figure<\/p>\n

Ma riconoscono il volto di una persona o imparano a distinguere tra le foto?<\/p>\n

Another interpretation of our data in the test-probe is that the high performance is an effect of rapid learning. We do not think, however, that an explanation of rapid learning is sufficient to explain our findings. Each tilted face is only presented once, yet the performance of the sheep over the whole session (12 presentations of the familiar faces in three orientations, plus three presentations of the image of the very familiar face) is significantly above chance. While rapid learning might be an explanation for the high performance in the detection of the very familiar face (the handler) because that was presented three times, recognition of a very familiar face (the handler) seems to be the more likely criterion on which they possibly base their choice decision.<\/p>\n

Perch\u00e9 sono abituate ad aver intorno tanta gente?<\/p>\n

One could also argue that the general domestication of sheep contributes to their abilities to recognize humans. However, the breed of our sheep, Welsh Mountain, is not one of the more easily managed\/tamed breeds. Indeed, they are characterized by their ability to survive independently of human support in the harsh environments in mountain areas.<\/p>\n","protected":false},"excerpt":{"rendered":"

Su Nature, l’editoriale\u00a0e sopratutto l’articolo\u00a0del gruppo diretto da Michele De Luca, univ. Modena e Reggio Emilia, spiegano le speranze suscitate dalla correzione di un dei geni che, se difettoso, causa l’epidermolisi bullosa, una malattia atroce di cui soffrono circa 500 mila persone. In June 2015, a seven-year-old child was admitted to the Burn Unit of… Continua a leggere Un bambino "farfalla" gioca a calcio<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,17],"tags":[5258,6196,6489],"class_list":["post-32871","post","type-post","status-publish","format-standard","hentry","category-altri-animali","category-genetica","tag-pecore","tag-scienze-cognitive","tag-staminali","entry"],"_links":{"self":[{"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/posts\/32871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/comments?post=32871"}],"version-history":[{"count":0,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/posts\/32871\/revisions"}],"wp:attachment":[{"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/media?parent=32871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/categories?post=32871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archivio.ocasapiens.org\/index.php\/wp-json\/wp\/v2\/tags?post=32871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}