Retraction alla napoletana, cont.

Il 18 ottobre, parlavo delle figure sospette di duplicazione, splicing ecc. negli articoli del prof. Alfredo Fusco, indagato anche dalla magistratura. Clare Francis mi segnala che il Journal of Clinical Investigations ha ritrattato questo del 2007.

Nel frattempo altri sono stati guardati da vicino, alcuni firmati da coautori, o da chi ne riprendeva i dati e anche alcuni metodi poco ortodossi, come segnalato da David Hardman nel thread di Retraction Watch. Anche il paper del 1987 esaminato da PubPeer è piuttosto imbarazzante.

Non sembra trattarsi di
uno o due errori su 7-8.000 pannelli…
o in un’altra  versione
di problemi di assemblaggio in 7-8 pannelli su settemila.
ma di centinaia di pannelli problematici negli ultimi 25 anni… Se ne occupa anche Der Spiegel.

*

Nello stesso thread, Maurizio “omnologos” Morabito nega di

a) negare l’effetto serra dei gas serra, mentre sostiene che il riscaldamento globale si sia fermato 16 anni fa (i dati, invece…) e che il riscaldamento di origine antropica – quello causato dalle nostre emissioni di gas serra – è un complotto di scienziati inetti, disonesti e pagati dagli ambientalisti (le sue bestie nere);
b) diffamare Michael Mann, mentre lo accusa di aver falsificato i dati della mazza da hockey come si vede dalla sua prefazione alla montagna di bufale da lui tradotta;
c) essere un ammiratore di Berlusconi, mentre lo elogia nei bollettini di partito da propagandista ufficiale di Forza Gn-UK

Shameless.

54 commenti

  2. 2013 Retraction for Marcello Maggiolini, scientific committee member of Associazione Italiana per la Ricerca sul Cancro (AIRC).
    http://retractionwatch.com/2013/12/12/herbicide-ovarian-cancer-study-to-be-retracted/
    Marcello is third up from the bottom on the left.
    http://www.airc.it/associazione/organi-sociali/direzione-scientifica/comitato-tecnico-scientifico/
    http://www.airc.it/english/scientific-committee/
    Marcello Maggiolini is also mentioned in these Pubpeer comments (the university addresses correspond).
    It is important to check them out.
    https://pubpeer.com/publications/19749156
    https://pubpeer.com/publications/16835357
    https://pubpeer.com/publications/19738069
    https://pubpeer.com/publications/19679653

  3. Also from Rende, Calabria, Sebastiano Andò.
    https://pubpeer.com/publications/19933843
    https://pubpeer.com/publications/16461930
    https://pubpeer.com/publications/12586841
    https://pubpeer.com/publications/17656605
    https://pubpeer.com/publications/19147702
    https://pubpeer.com/publications/17409452
    https://pubpeer.com/publications/20067470
    https://pubpeer.com/publications/21737614
    Sebastiano Andò is a member of the scientific fellowship committee of the Associazione Italiana per la Ricerca sul Cancro (AIRC)
    Top right in the websites below.
    http://www.airc.it/associazione/organi-sociali/direzione-scientifica/comitato-scientifico-borse-di-studio/
    http://www.airc.it/english/scientific-fellowship-committee/

  4. A clear example.
    FASEB J. 2003 Aug;17(11):1496-8. Epub 2003 Jun 17.
    Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation.
    Sabrina Battista,*,†Francesca Pentimalli,* Gustavo Baldassarre,†Monica Fedele,*Vincenzo Fidanza,†Carlo M. Croce,†and Alfredo Fusco*
    Dipartimento di Biologia e Patologia Cellulare
    e Molecolare, c/o Centro di Endocrinologia ed
    Oncologia Sperimentale del CNR, Facoltà di Medi
    cina e Chirurgia, Università degli Studi di
    Napoli “Federico II,” Naples, Italy; and
    †
    Kimmel Cancer Institute, Jefferson Medical College,
    Philadelphia 19107, Pennsylvania, USA
    Source
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, via Pansini 5, 80131 Naples, Italy.
    PMID: 12824305 (unique identifying number).
    Full article. The figures are at the end of the webpage.
    http://www.fasebj.org/content/early/2003/07/31/fj.02-0977fje
    Please go to 200%.
    Figure 1B. Vertical, straight change background to left of band lane 2.
    Please compare signal in lanes 2 and 3, paying attention to the 2 dark bubbles at the lower edge of the upper band in lanes 2 and 3, and the two light spots above the bands.
    The signal in adjacent lanes should not be so similar.
    Ten years is no time in science.

  6. You may want to consider this. It may need editing, but is quite important.
    http://english.pte.hu/index.php?p=contents&cid=441
    “Dr. Pier Giorgio Natali was the director of the Regina Elena Cancer Institute, Division of Immunology in Rome until his retirement on 31st December in 2008.”
    There is some debate about the authenticity of several papers authored by Dr. Pier Giorgio Natali. There do seem to be irregularities on the page.
    This entry gives an idea of the debate. An entry was made. Another person thought the comments were unfair. A third person pointed out that there are irregularities in several other papers.
    https://pubpeer.com/publications/12875994
    These entries give more substance to the concerns about authenticity of other publications.
    https://pubpeer.com/publications/19276384
    https://pubpeer.com/publications/17620430
    https://pubpeer.com/publications/16648553
    https://pubpeer.com/publications/14973117
    https://pubpeer.com/publications/19202075
    https://pubpeer.com/publications/17308114
    https://pubpeer.com/publications/20574527
    Something is not quite right. My guess is that it is the entire system. The scientific system is only a subset of the national system.
    Why should if be different? Other national systems also have their problems. Some very well hidden. For example, England has since 1066 to practise.
    This is an interesting read:
    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0021160

  8. The vice-rector for research for the University of Naples, Roberto Di Lauro, is conflicted and confused. He is leading the internal inquiry into 60 publications by A Fusco, yet has published 9 scientific papers with A Fusco.
    http://www.nature.com/news/image-search-triggers-italian-police-probe-1.14295
    “A source close to the police investigation confirms that around 60 papers by Fusco are being studied, including a 2007 paper in the Journal of Clinical Investigation that was retracted by the editors in November.
    When details of the inquiry were leaked to an Italian newspaper in October, the rector of Fusco’s university set up a three-man internal committee headed by Roberto Di Lauro, vice-rector for research at the University of Naples, that is expected to report by the end of the year. Di Lauro has co-authored nine papers with Fusco,”.
    In a comment to the Nature article, a Roberto Di Lauro, writes”
    “As vice-rector for research I felt that I had to comply with my rector request, even though I have co-authored 9 papers with Fusco. Of these, 7 were published before 1985”.
    Another commentator, Beatrice Mueller, has pointed out a flaw in his argument.
    Beatrice Mueller •
    In reply to Roberto Di Lauro, Rector of Naples University,
    You wrote “even though I have co-authored 9 papers with Fusco. Of these, 7 were published before 1985”. Does that apply to degrees issued by the University of Naples? Do the degrees before 1985 become invalid?
    I think that one of your publications with A Fusco from 1985 is highly relevant.
    J Virol. 1985 Oct;56(1):284-92.
    A mos oncogene-containing retrovirus, myeloproliferative sarcoma virus, transforms rat thyroid epithelial cells and irreversibly blocks their differentiation pattern.
    Fusco A, Portella G, Di Fiore PP, Berlingieri MT, Di Lauro R, Schneider AB, Vecchio G. PMID: 2993656
    Please follow the simple instructions below.
    https://pubpeer.com/publications/2993656
    Why did Roberto Di Lauro feel a need with a request when he is conflicted? Why not simply and clearly point out the conflict of interest? The rector of Naples university would at least know about the conflict of interest.

  9. Another very interesting publication by professor Francesco Beguinot, Napoli has been noted at Pubpeer.
    https://pubpeer.com/publications/16216880
    The figures are at the end of the webpage directly below.
    http://www.jbc.org/content/early/2005/10/10/jbc.M508570200
    Figure 1B. alpha-PKC-alpha panel. Please compare bands lanes 2 and 3.
    Horizontal change background above band lane 2.
    Figure 3A. Please compare signal in lanes 2 and 3.
    Please compare bands at top of lanes 2,3 and 4.
    Figure 3B. Please compare bands in left 5 lanes.
    Figure 3C.
    Alpha-IRS-1 panel. Please compare bands lanes 1 and 2.
    Alpha-IRS-2 panel. Please compare bands lanes 3 and 4.
    Figure 3D. Please compare bands lanes 1 and 4.
    Figure 3E. Please compare bands lanes 1,3,4,5 and 6.
    Figure 4D. Alpha-pRaf-1 panel. Please compare bands lanes 2 and 3.
    Figure 4E. Alpha-Foxo1 panel. Please compare signal lanes 3 and 4 with signal lanes 1 and 2 respeactively.
    Alpha-Akt/PKB panel. Please compare signal lanes 1 and 4.
    Figure 5B. Alpha-PKC-alpha panel. Please compare bands lanes 2 and 4.
    Figure 6A. Alpha-14-3-3-beta panel. Please compare bands lanes 2,3 and 4.
    Figure 7A. Alpha-IR panel. Please compare bands lanes 1 and 2.
    Please compare bands lanes 2 and 3.
    Figure 7D.
    Alpha-pAkt/PKB panel. Lane 4 has smoother background than other 3 lanes.
    Alpha-pFoxo1 panel. Please compare signal lanes 3 and 4.
    Alpha-Foxo1 panel. Please compare signal lanes 1 and 2. Please compare signal lanes 3 and 4.
    Figure 8. I.P. alpha-IRS-1/W.B. alpha-PY panel. Please compare bands lanes 1,3,4,5 and 6.
    Please compare bands lane 8 with horizontal mirror image band lane 2.
    Alpha-pAkt/PKB panel. Please compare signal lanes 4 and 6.
    Figure 10A. Please compare signal lanes 1 and 2. Please compare signal lanes 3 and 4.

  10. Interesting publication by professor Fulvio Della Ragione, Napoli.
    https://pubpeer.com/publications/16210343
    Blood. 2006 Jan 15;107(2):514-9. Epub 2005 Oct 6.
    Von Hippel-Lindau-dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster.
    Perrotta S, Nobili B, Ferraro M, Migliaccio C, Borriello A, Cucciolla V, Martinelli V, Rossi F, Punzo F, Cirillo P, Parisi G, Zappia V, Rotoli B, Della Ragione F.
    Department of Pediatrics, Second University of Naples, Via Luigi De Crecchio, 4, Naples, Italy.
    My observations.
    Figure 2.
    http://bloodjournal.hematologylibrary.org/content/107/2/514/F2.large.jpg
    Figure 2B. Please compare signal P24 and p25 lanes, paying attention to the background and signal between the bands.
    Vertical, straight grey streak betweenM and Control lanes.
    Smooth area between balds Control lane.
    Smooth areas at bottom of lanes P04 and rightwards until the end.
    Figure 3.
    http://bloodjournal.hematologylibrary.org/content/107/2/514/F3.large.jpg
    Figure 3A. Please compare lower bands lanes 2,3 and 4.
    Also, please note horizontal, straight change in signal just above lower bands in lanes 2,3 and 4.
    Figure 3B. Actin lane. About 20 repeats of a vertical pattern.
    Figure 4.
    http://bloodjournal.hematologylibrary.org/content/107/2/514/F4.large.jpg
    Figure 4B. HIF-1alpha panel. Vertical change background between P12 and P 22 lanes.
    Figure 5.
    http://bloodjournal.hematologylibrary.org/content/107/2/514/F5.large.jpg
    Figure 5B. Please compare VEGF panel figure 5B with 180 degree rotation lanes 1 and 2 EPO panel figure 5A.

  12. Mol Med. 2009 Mar-Apr;15(3-4):76-84. doi: 10.2119/molmed.2008.00108. Epub 2008 Nov 19.
    CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbus.
    Horenstein AL, Sizzano F, Lusso R, Besso FG, Ferrero E, Deaglio S, Corno F, Malavasi F.
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy.
    Figure 2.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=2646820_mol-15-76f2.jpg
    Figure 2A. Epthelium panel. Vertical change background between middle and right lanes.
    No vertical changes background in stroma panel.

  13. Am J Pathol. 2003 Apr;162(4):1163-74.
    Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells.
    Righi L, Deaglio S, Pecchioni C, Gregorini A, Horenstein AL, Bussolati G, Sapino A, Malavasi F.
    Department of Genetics, Biology, and Biochemistry, Laboratory of Immunogenetics, University of Torino Medical School, Torino, Italy.
    Figure 2.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=1851235_jh0433570002.jpg
    Figure 2B. Right panel. Vertical change background between left and right lanes.
    Figure 2C. Right panel. Vertical change background between left and right lanes.

  14. J Immunol. 2008 Feb 1;180(3):1471-81.
    IFN-gamma arms human dendritic cells to perform multiple effector functions.
    Frasca L, Nasso M, Spensieri F, Fedele G, Palazzo R, Malavasi F, Ausiello CM.
    Department of Infectious, Parasitic, and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
    Figure 5.
    http://www.jimmunol.org/content/180/3/1471/F5.large.jpg
    Figure 5A. Right pSTAT1 panel. Vertical change background between lanes 1 and 2.
    No vertical changes background in right STAT1 panel.
    pIkappaBalpha panel. Vertical change background between lanes 1 and 2.
    pp38 panel. Vertical change background between lanes 2 and 3.
    No vertical changes in background in the accompanying beta-tubulin panels.
    SAPK/JNK panel. Vertical change background between lanes 2 and 3.
    No vertical changes in background in the accompanying beta-tubulin panel.

  15. Blood. 2006 Dec 15;108(13):4214-22. Epub 2006 Aug 17.
    CD157 plays a pivotal role in neutrophil transendothelial migration.
    Ortolan E, Tibaldi EV, Ferranti B, Lavagno L, Garbarino G, Notaro R, Luzzatto L, Malavasi F, Funaro A.
    Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Medical School, Via Santena 19, 10126 Torino, Italy.
    Figure 1.
    http://bloodjournal.hematologylibrary.org/content/108/13/4214/F1.large.jpg
    Figure 1C. Vertical, straight change in background between left and right lanes. There are only 2 lanes.

  16. Cancer Res. 2004 Nov 15;64(22):8156-9.
    Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer.
    Miotto E, Sabbioni S, Veronese A, Calin GA, Gullini S, Liboni A, Gramantieri L, Bolondi L, Ferrazzi E, Gafà R, Lanza G, Negrini M.
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy.
    Figure 1.
    http://cancerres.aacrjournals.org/content/64/22/8156/F1.large.jpg
    Figure 1C.
    Methylation panel.
    Please compare lanes 12 and 13 with lanes 8 and 9, paying attention to dark spots in the background.
    Please compare lanes 10 and 11 with lanes 6 and 7 and with lanes 4 and 5.
    Expression panel.
    Please compare bands lanes 12 and 13 with bands lanes 8 and 9.
    Please compare signal lanes 10 and 11.
    Figure 2.
    http://cancerres.aacrjournals.org/content/64/22/8156/F2.large.jpg
    Figure 2B.
    Tumor panel. Please compare signal PBL and #3216 lanes with signal #3223 and #3215 lanes.
    Please compare signal #3275, #3277 and #3280 lanes.

  20. Retraction. European Journal of Pharmacology
    Available online 27 January 2014.
    http://www.sciencedirect.com/science/article/pii/S0014299914000259
    Retraction notice to “PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines” [Eur. J. Pharmacol. 714(1–3) (2013) 379–387]
    Giuseppina Gangemia, Patrizia Gazzerroa, Donatella Fiorea, Maria Chiara Protoa, Stefania Butinib, c, Sandra Gemmab, c, Alice Casagnib, c, Chiara Laezzaf, Mario Vitaleg, Alessia Ligrestid, Vincenzo DiMarzod, Daniela M. Zisterere, Seema Nathwanie, D. Clive Williamse, Giuseppe Campianib, c, Maurizio Bifulco g
    a Department of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy
    b European Research Centre for Drug Discovery and Development (Nat Syn Drugs), University of Siena, Via Aldo Moro, 53100 Siena, Italy
    c Dipartimento Farmaco Chimico Tecnologico, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    d Institute of Biomolecular Chemistry, C.N.R., Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy
    e School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    f Institute of Endocrinology and Experimental Oncology, IEOSCNR, Via Pansini 5, 80131 Naples, Italy
    g Department of Medicine and Surgery, University of Salerno, Via S. Allende, Baronissi 1-84081, SA, Italy
    Refers To
    Giuseppina Gangemi, Patrizia Gazzerro, Donatella Fiore, Maria Chiara Proto, Stefania Butini, Sandra Gemma, Alice Casagni, Chiara Laezza, Mario Vitale, Alessia Ligresti, Vincenzo Di Marzo, Daniela M. Zisterer, Seema Nathwani, D. Clive Williams, Giuseppe Campiani, Maurizio Bifulco
    RETRACTED: PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines
    European Journal of Pharmacology, Volume 714, Issues 1–3, 15 August 2013, Pages 379-387
    PDF (1084 K)
    This article has been retracted at the request of the authors.
    Upon close inspection, the co-authors realized that the first author (Giuseppina Gangemi) substantially manipulated some of the western blot figures reported in the paper. None of the other authors are responsible for this occurrence. Even though the main conclusions are not affected by such manipulations, they wish to retract this publication, and apologize for the confusion and inconvenience caused.
    The publisher apologizes for the inconvenience caused.

  21. Int J Cancer. 2009 Mar 15;124(6):1322-9. doi: 10.1002/ijc.24056.
    N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1.
    Laezza C, Caruso MG, Gentile T, Notarnicola M, Malfitano AM, Di Matola T, Messa C, Gazzerro P, Bifulco M.
    Author information
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy.
    http://onlinelibrary.wiley.com/doi/10.1002/ijc.24056/pdf
    Figure 3. p21 waf panel. Vertical, straight change background between 50 microM 12 and 24 hrs lanes. It is supposed to be a time series.
    Actin panel. Please compare bands 10 microM 6 and 12 hrs lanes.
    They are not the same, but there are many similarities.
    Figure 5.
    Figure 5a. p38 panel. Please compare bands lanes 7 and 8 with bands lanes 1 and 2.
    Please compare bands lanes 3,6 and 9, paying attention to the dark dot at their left ends.
    Figure 5b. p38 panel. Please compare bands lanes 6 and 7 with smaller versions bands lanes 2 and 3.

  22. Circ Res. 2005 Mar 18;96(5):501-8. Epub 2005 Feb 10.
    Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress.
    Illi B, Scopece A, Nanni S, Farsetti A, Morgante L, Biglioli P, Capogrossi MC, Gaetano C.
    Author information
    Laboratorio di Biologia Vascolare e Terapia Genica, Centro Cardiologico Fondazione I. Monzino IRCCS, Milan, Italy.
    Figure 1.
    http://circres.ahajournals.org/content/96/5/501/F1.large.jpg
    Figure 1A. H3PhS10 panel.
    Band lane 4 has vertical, straight right edge.
    Please compare bands lanes 3 and 4 with bands lanes 1 and 2.
    Band lane 6 has vertical, straight right edge.
    Please compare bands lanes 5 and 6 with vertically compressed versions bands lanes 11 and 12.
    Please compare bands lanes 7 and 8 with bands lanes 9 and 10.
    Figure 4.
    http://circres.ahajournals.org/content/96/5/501/F4.large.jpg
    Figure 4A. Band right TBX 3 lane has horizontal, straight top.
    Band right GAPDH lane has vertical, straight right edge.

  23. Circ Res. 2008 Jan 4;102(1):51-8. Epub 2007 Nov 1.
    Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling.
    Illi B, Dello Russo C, Colussi C, Rosati J, Pallaoro M, Spallotta F, Rotili D, Valente S, Ragone G, Martelli F, Biglioli P, Steinkuhler C, Gallinari P, Mai A, Capogrossi MC, Gaetano C.
    Author information
    Laboratorio di Biologia Vascolare e Terapia Genica, Centro Cardiologico Fondazione I. Monzino, IRCCS, Milan, Italy.
    Figure 1.
    http://circres.ahajournals.org/content/102/1/51/F1.large.jpg
    Figure 1A. H3AcK14 panel. Vertical, straight change background between lanes 2 and 3. It is supposed to be a time series.
    Figure 1C. Left H1 panel. Vertical, straight edge signal band middle lane.

  24. Circ Res. 2000 Feb 18;86(3):312-8.
    Acidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression.
    D’Arcangelo D, Facchiano F, Barlucchi LM, Melillo G, Illi B, Testolin L, Gaetano C, Capogrossi MC.
    Author information
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell’Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
    Figure 6.
    http://circres.ahajournals.org/content/86/3/312/F6.large.jpg
    Figure 6A. Vertical, light streaks/vertical changes background between left and right lanes in left and right beta-actin panels.
    No vertical changes in background in VEGF or bFGF panels.

  25. Stem Cells. 2010 Mar 31;28(3):431-42. doi: 10.1002/stem.300.
    Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia.
    Spallotta F, Rosati J, Straino S, Nanni S, Grasselli A, Ambrosino V, Rotili D, Valente S, Farsetti A, Mai A, Capogrossi MC, Gaetano C, Illi B.
    Author information
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell’ Immacolata – Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
    http://onlinelibrary.wiley.com/doi/10.1002/stem.300/pdf
    Figure 6A.
    HDAC7 panel.
    Please compare middle lane with horizontal mirror image left lane.
    Red Ponceau panel.
    Please compare signal middle lane with signal left lane.

  26. Circulation. 2004 Jun 15;109(23):2917-23. Epub 2004 Jun 1.
    p66ShcA modulates tissue response to hindlimb ischemia.
    Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, Biglioli P, Giorgio M, Martin-Padura I, Pelicci PG, Capogrossi MC.
    Author information
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell’Immacolata-IRCCS, Rome, Italy.
    Figure 1.
    http://circ.ahajournals.org/content/109/23/2917/F1.large.jpg
    Figure 1A. VEGF panel. Vertical, straight changes in signal between lanes 2,3,4, 5 and between lanes 6,7 and 8.
    RED PONCEAU panel. Vertical changes in background between lanes 1,2,3,4,5 and 6,7 and 8.
    Figure 2.
    http://circ.ahajournals.org/content/109/23/2917/F2.large.jpg
    Vertical, straight changes in signal between left and right lanes, both panels.

  27. New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells
    Alessandra Rossi * † , Silvia Schenone § , Adriano Angelucci ? , Martina Cozzi † , Valentina Caracciolo * , Francesca Pentimalli * ¶ , Andrew Puca * , Biagio Pucci ¶ , Raffaele La Montagna * , Mauro Bologna ? , Maurizio Botta ‡ and Antonio Giordano * † ¶ , 1
    – Author Affiliations
    *Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA;
    †Department of Human Pathology and Oncology and
    ‡Dipartimento Farmaco Chimico Tecnologico, University of Siena, Siena, Italy;
    §Department of Pharmaceutical Science, University of Genoa, Genoa, Italy;
    ?Department of Experimental Medicine, University of L’Aquila, L’Aquila, Italy; and
    ¶CROM-Center of Oncology Research Mercogliano, Avellino, Italy.
    Full document.
    http://www.fasebj.org/content/24/8/2881.full.pdf+html
    Figure 3.
    http://www.fasebj.org/content/24/8/2881/F3.large.jpg
    Figure 3A. c-Src panels.
    Please compare bands in lanes 1,2 and 3 of the 72hrs (right) panel with the bands in lanes 2,3 and 4 of the 24hrs (left) panel, paying attention to the dot above the band lane 1 72hrs panel and lane 2 24hrs panel.
    Please compare the band lane 4 of the 48hrs panel with band lane 1 of the 24hrs panel.
    Phospho-Src panels.
    Please compare the band lane 1 48hrs panel with an enlarged version of the band lane 1 of the 72hrs panel, paying attention to the dot below the middle of the bands.
    Figure 4.
    http://www.fasebj.org/content/24/8/2881/F4.large.jpg
    Please compare 72hrs beta-actin panel figure 4C with 6hrs cdc2 panel figure 3B.
    Please also see Pubpeer.
    https://pubpeer.com/publications/20354138

  28. Int J Cancer. 2013 Dec 1;133(11):2650-61. doi: 10.1002/ijc.28280. Epub 2013 Jul 9.
    HtrA1 in human urothelial bladder cancer: a secreted protein and a potential novel biomarker.
    Lorenzi T, Lorenzi M, Altobelli E, Marzioni D, Mensà E, Quaranta A, Paolinelli F, Morroni M, Mazzucchelli R, De Luca A, Procopio AD, Baldi A, Muzzonigro G, Montironi R, Castellucci M.
    Author information
    Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Via Tronto 10/a, Ancona, 60020, Italy.
    http://onlinelibrary.wiley.com/doi/10.1002/ijc.28280/pdf
    Figure 2c. Please compare signal in T24 lysate and medium lanes with signal in TCC-SUP lysate and medium lanes respectively.
    The cells are different.

  29. PLoS One. 2012;7(5):e35232. doi: 10.1371/journal.pone.0035232. Epub 2012 May 11.
    Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage.
    Lorenzi T, Turi A, Lorenzi M, Paolinelli F, Mancioli F, La Sala L, Morroni M, Ciarmela P, Mantovani A, Tranquilli AL, Castellucci M, Marzioni D.
    Author information
    Division of Neuroscience and Cell Biology, Department of Experimental and Clinical Medicine, School of Medicine, Università Politecnica delle Marche, Ancona, Italy.
    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0035232
    Figure 7.
    Second MC CD72 panel. Please compare signal lanes 1 and 2.
    Third MC CD72 panel. Please compare signal lanes 1 and 2.
    First MC CD 72 panel. Looks like it was done by a painter. Doubt authenticity.
    Please compare the first and third MC actin panels. There are differences, but many similarities.
    Only the bands in the first lanes are truly different.
    Please compare the first trimester and second MC actin panels. There are differences, but many similarities.
    Only the bands in the 4th lanes are truly different.
    Figure 9.
    Second MC CD45 panel. Please compare background lanes 1 and 2.
    Please compare backgrounds upper halves lanes 5 and 6.
    Fourth MC CD45 panel. Please compare the background in the lower halves of lanes 2 and 3.
    Please compare the background in the lower half of lane 5 with a horizontal mirror image of the background in the lower half of lane 4.
    Please compare the background in the lower half of lane 6 with a horizontal mirror image of the background in the lower half of lane 1.

  31. EMBO J. 2002 Sep 16;21(18):4875-84.
    Dual mode of degradation of Cdc25 A phosphatase.
    Donzelli M1, Squatrito M, Ganoth D, Hershko A, Pagano M, Draetta GF.
    Author information
    1European Institute of Oncology, 435 Via Ripamonti, I-20141 Milan, Italy.
    PMID: 12234927
    Figure 4.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=126287_cdf491f4.jpg
    Figure 4A. Cdc25 A-(Ub)n/35S-Cdc25 A (left) panel.
    Please compare signal in lanes 1,2 and 5, paying attention to the light areas inside the dark bands at the bottom of the lanes and also to the series of dark and light spots in the trail above the dark bands.
    Those 3 lanes are supposed to represent different treatments. Even if they were the same treatment the signals in different lanes should not be the same.
    Dark band at bottom of lane 3 has vertical, straight left edge.
    Figure 4B. Vertical, straight change background between bottom halves lanes 2 and 3.

  32. J Clin Invest. 2000 Sep;106(6):753-61.
    Role of the Cdc25A phosphatase in human breast cancer.
    Cangi MG1, Cukor B, Soung P, Signoretti S, Moreira G Jr, Ranashinge M, Cady B, Pagano M, Loda M.
    Author information
    1Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA.
    PMCID:PMC381390
    Figure 4.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=381390_JCI0009174.f4.jpg
    Figure 4b. Please compare bands and background in lanes 1 and 3, paying attention to the light spot above the middle left of the bands just below the top of the lanes. Please compare bands lanes 4 and 6.
    Figure 1.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=381390_JCI0009174.f1.jpg
    Figure 1a.
    Left Cdk2 H1 kinase panel. Vertical, straight changes signal between lanes 1,2 and 3.
    Figure 3.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=381390_JCI0009174.f3.jpg
    Figure 3a. Cdc25A RT-PCR panel. Vertical, straight changes in background between lanes 3,4 and 5.
    Figure 3b. Cdk4 Rb kinase panel. Vertical, straight, light streaks/vertical changes in background between lanes 1,2 and 3.

  33. J Clin Invest. 2002 Sep;110(5):633-41.
    Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.
    Signoretti S1, Di Marcotullio L, Richardson A, Ramaswamy S, Isaac B, Rue M, Monti F, Loda M, Pagano M.
    Author information
    1Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
    Figure 5.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=151109_JCI0215795.f5.jpg
    Figure 5. Cyclin D1 panel. Please compare band lane 2 and band lane 6, paying attention to the dark spot about one bandwith above the middle right of the bands.

  34. Eur J Cancer. 2011 Feb;47(3):470-8. doi: 10.1016/j.ejca.2010.09.045. Epub 2010 Oct 31.
    Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice.
    Fedele M1, Visone R, De Martino I, Palmieri D, Valentino T, Esposito F, Klein-Szanto A, Arra C, Ciarmiello A, Croce CM, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
    PMID: 21044834
    Figure 1D. Please compare lanes 2 to 7 Gapdh panel with slightly longer exposure lanes 1 to 6 Hmga1b/T panel respectively,
    i.e. shifted over 1 lane to the right.

  35. Eur J Cancer. 2007 Dec;43(18):2729-35. Epub 2007 Oct 22.
    UbcH10 is overexpressed in malignant breast carcinomas.
    Berlingieri MT1, Pallante P, Sboner A, Barbareschi M, Bianco M, Ferraro A, Mansueto G, Borbone E, Guerriero E, Troncone G, Fusco A.
    Author information
    1Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, via S.Pansini 5, 80131 Naples, Italy.
    PMID: 17933517
    Figure 4. ErB2 panel. Please compare distinctive shapes bands lanes 2 and 4. The bands are a different shade of grey.

  36. Oncogene. 2010 Mar 4;29(9):1384-93. doi: 10.1038/onc.2009.430. Epub 2009 Dec 7.
    The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.
    Peschiaroli A1, Skaar JR, Pagano M, Melino G.
    Author information
    1IDI IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.
    Figure 6.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869786/figure/F6/
    Please compare left 4 lanes Actin panel figure 6b with Skp1 panel figure 3d.
    Figure 3.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869786/figure/F3/

  37. J Biol Chem. 2006 Aug 4;281(31):22100-7. Epub 2006 Jun 5.
    Up-regulation of Skp2 after prostate cancer cell adhesion to basement membranes results in BRCA2 degradation and cell proliferation.
    Moro L1, Arbini AA, Marra E, Greco M.
    Author information
    1Institute of Biomembranes and Bioenergetics, National Research Council, Bari 70126, Italy.
    http://www.jbc.org/content/early/2006/06/05/jbc.M604636200
    Figure 5A. a-BRCA2 panel. Please compare band lane 4 with vertical mirror image band lane 1.
    Figure 6B. P-AKT panel. Please compare bands lanes 1 and 5.
    Figure 7A. BRCA2 panel. Please compare bands lanes 2 and 4.

  38. Eur J Endocrinol. 2001 Nov;145(5):645-50.
    Lovastatin-induced apoptosis in thyroid cells: involvement of cytochrome c and lamin B.
    Di Matola T, D’Ascoli F, Luongo C, Bifulco M, Rossi G, Fenzi G, Vitale M.
    Author information
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Via S Pansini 5, 80131, Naples, Italy.
    http://eje-online.org/content/145/5/645.long
    Figure 3B. Please compare the backgrounds in the 12 and 24 hour lanes.

  39. Oncogene. 1998 Jul 23;17(3):377-85.
    Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo.
    Battista S1, de Nigris F, Fedele M, Chiappetta G, Scala S, Vallone D, Pierantoni GM, Mega T, Santoro M, Viglietto G, Verde P, Fusco A.
    Author information
    1Instituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Oncologia Sperimentale D ed E, Italia.
    From Pubpeer:
    https://pubpeer.com/publications/AB32B760C5C73A7444110A1C0180CB#fb7339
    http://www.nature.com/onc/journal/v17/n3/pdf/1201953a.pdf
    Figure 4. H2B panel.
    Vertical light streaks between lanes 10 and 11, and between lanes 14 and 15.
    Please compare bands lanes 11 to 14 with bands lanes 4 to 7.
    Collagenase panel. Change in background between lanes 3 and 4.
    Figure 2. Fra-1 panel. Vertical change background between lanes 11 and 12.
    Figure 3. GAPDH panel. Vertical, light streaks between bands. Many band have subtle, light diagonal streak through them.
    Figure 8. c-Jun panel. Subtle, vertical changes in background between lanes 2,3,4 and 5.

  40. Circulation. 2012 Oct 9;126(15):1869-81. doi: 10.1161/CIRCULATIONAHA.112.118380. Epub 2012 Sep 6.
    Cardiomyogenesis in the aging and failing human heart.
    Kajstura J1, Rota M, Cappetta D, Ogórek B, Arranto C, Bai Y, Ferreira-Martins J, Signore S, Sanada F, Matsuda A, Kostyla J, Caballero MV, Fiorini C, D’Alessandro DA, Michler RE, del Monte F, Hosoda T, Perrella MA, Leri A, Buchholz BA, Loscalzo J, Anversa P.
    Author information
    1Department of Anesthesia, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
    Notice of retraction.
    http://circ.ahajournals.org/content/early/2014/04/08/CIR.0000000000000049
    “For the article by Jan Kajstura, Marcello Rota, Donato Cappetta, Barbara Ogórek, Christian Arranto, Yingnan Bai, João Ferreira Martins, Sergio Signore, Fumihiro Sanada, Alex Matsuda, James Kostyla, Maria-Virginia Caballero, Claudia Fiorini, David A. D’Alessandro, Robert E. Michler, Federica del Monte, Toru Hosoda, Mark A. Perrella, Annarosa Leri, Bruce A. Buchholz, Joseph Loscalzo, and Piero Anversa (Cardiomyogenesis in the aging and failing human heart. Circulation. 2012;126:18691881; DOI: 10.1161/CIRCULATIONAHA.112.118380), an ongoing institutional review by Harvard Medical School and Brigham and Women’s Hospital has determined that the data are sufficiently compromised that a retraction is warranted.
    The American Heart Association, therefore, retracts the article.”
    http://retractionwatch.com/2014/04/08/harvard-and-the-brigham-investigating-leading-heart-group-for-compromised-data/

  41. Cancer Res. 2007 May 1;67(9):4278-86.
    The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration.
    Voena C1, Conte C, Ambrogio C, Boeri Erba E, Boccalatte F, Mohammed S, Jensen ON, Palestro G, Inghirami G, Chiarle R.
    Author information
    1Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
    There is already https://pubpeer.com/publications/3686590C34E1C9C0F408043BD65EBA#fb8083
    Also, figure 5C.
    http://cancerres.aacrjournals.org/content/67/9/4278/F5.large.jpg
    SU-DHL-1 TTA Shp2 panels.
    Please compare Control + (plus) lane with longer exposure Shp2 shRNA – (minus) lane,
    paying attention to the diagonal grey streak above the central left of the bands.

  42. Third A Fusco retraction.
    http://www.nature.com/cddis/journal/v5/n5/full/cddis2014163a.html
    Retraction
    Citation: Cell Death and Disease (2014) 5, e1206; doi:10.1038/cddis.2014.163
    Published online 1 May 2014
    Retraction to: High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria
    F Esposito, M Tornincasa, A Federico, G Chiappetta, G M Pierantoni and A Fusco
    Retraction to: Cell Death and Disease (2012) 3, e383; doi:10.1038/cddis.2012.126; published online 30 August 2012
    The Editorial Board of Cell Death and Disease is retracting the above article (PMID 22932725).
    A reader contacted the Editors about apparent duplications in Figures 1b and 2c, and possible splicing of an image in Figure 3c. Concerns were subsequently raised about the similarity of the tubulin loading controls in Figure 1b to those that appeared in Figure 1c of Cell Death and Differentiation 2006; 13: 1554–63 (PMID 16341121), a paper that was retracted by the authors on 6 December 2013.
    Because the Authors were unable to provide the original source files that were used to generate the figures in question, the Editorial Board is retracting this publication.

  43. Fourth retraction A Fusco. DNA and Cell Biology. March 2014, 33(3): 189-189. doi:10.1089/dna.2008.0778.retract.
    http://online.liebertpub.com/doi/full/10.1089/dna.2008.0778.retract
    The article entitled “Targeted Disruption of the Murine Homeodomain-Interacting Protein Kinase-2 Causes Growth Deficiency In Vivo and Cell Cycle Arrest In Vitro,” by Trapasso et al., 2009;28(4);doi: 10.1089/dna.2008.0778, pp 161–167, is being officially retracted from DNA and Cell Biology.
    Data presented in Figure 1 appear to have been manipulated.
    We regret any inconvenience this error may have caused.
    Original article:
    DNA Cell Biol. 2009 Apr;28(4):161-7. doi: 10.1089/dna.2008.0778.
    Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.
    Trapasso F1, Aqeilan RI, Iuliano R, Visone R, Gaudio E, Ciuffini L, Alder H, Paduano F, Pierantoni GM, Soddu S, Croce CM, Fusco A.
    Author information
    1Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

  44. http://www.jci.org/articles/view/76855
    Published in Volume 124, Issue 6 (June 2, 2014)
    J Clin Invest. 2014;124(6):2807–2807. doi:10.1172/JCI76855.
    Copyright © 2014, American Society for Clinical Investigation
    Retraction
    View original article
    The IL-12R?2 gene functions as a tumor suppressor in human B cell malignancies
    Irma Airoldi, Emma Di Carlo, Barbara Banelli, Lidia Moserle, Claudia Cocco, Annalisa Pezzolo, Carlo Sorrentino, Edoardo Rossi, Massimo Romani, Alberto Amadori and Vito Pistoia
    Published June 2, 2014
    Original citation: J. Clin. Invest. 2004;113(11):1651–1659. doi:10.1172/JCI20303.
    Citation for this retraction: J. Clin. Invest. 2014;124(6):2807. doi:10.1172/JCI76855.
    It has come to our attention that multiple gel images in Figure 1A were inappropriately duplicated from a previous publication (Airoldi I. et al. Expression and function of IL-12 and IL-18 receptors on human tonsillar B cells. J Immunol. 2000;165(12):6880–6888) in violation of JCI editorial policy. The experimental results presented in Figure 1A were intentionally mislabeled as representing total tonsil B lymphocytes and naive, GC, and memory B cells from the same tonsil, in contrast with the sample labeling in the previous publication. The JCI editorial board is retracting this article due to the evident misrepresentation of data and image duplication. No issues have been raised in regard to any of the other data in this manuscript.

  45. Neoplasia. 2006 Oct;8(10):833-42.
    Tumor mRNA-transfected dendritic cells stimulate the generation of CTL that recognize neuroblastoma-associated antigens and kill tumor cells: immunotherapeutic implications.
    Morandi F1, Chiesa S, Bocca P, Millo E, Salis A, Solari M, Pistoia V, Prigione I.
    Author information
    1Laboratory of Oncology, G. Gaslini Children’s Hospital, Genoa, Italy.
    PMID:17032500
    Figure 1.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=1715922_neo0810_0833_fig001.jpg
    Please see figure 1A.
    Pubpeer reporting: https://pubpeer.com/publications/C3110D52003332DE7C0F46DE944BDF#fb10629
    incuding imgur images:
    http://i.imgur.com/aqGI72B.jpg

  48. Cancer Lett. 2010 May 28;291(2):230-6. doi: 10.1016/j.canlet.2009.10.017.
    Fhit loss in lung preneoplasia: relation to DNA damage response checkpoint activation.
    Cirombella R1, Montrone G, Stoppacciaro A, Giglio S, Volinia S, Graziano P, Huebner K, Vecchione A.
    Author information
    1Division of Pathology, II University of Rome La Sapienza, Ospedale Santo Andrea, Rome, Italy.
    PMID: 19931269
    Figure 1.
    http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=2849884_nihms160608f1.jpg
    Please see: https://pubpeer.com/publications/499D4D40914B863806C7A6E10B34AE

  50. 8th retraction Alfredo Fusco.
    Eur J Cancer. 2011 Feb;47(3):470-8. doi: 10.1016/j.ejca.2010.09.045. Epub 2010 Oct 31.
    Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice.
    Fedele M1, Visone R, De Martino I, Palmieri D, Valentino T, Esposito F, Klein-Szanto A, Arra C, Ciarmiello A, Croce CM, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
    Retraction.
    http://www.sciencedirect.com/science/article/pii/S0959804915002142
    Pubpeer.
    https://pubpeer.com/publications/DB09C09E8DF6A785A7A2B98A81E283#fb27724

  51. 9th retraction for Alfredo Fusco.
    J Clin Invest. 2005 Apr;115(4):1068-81. Epub 2005 Mar 10.
    The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
    Melillo RM1, Castellone MD, Guarino V, De Falco V, Cirafici AM, Salvatore G, Caiazzo F, Basolo F, Giannini R, Kruhoffer M, Orntoft T, Fusco A, Santoro M.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G. Salvatore, Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Naples, Italy.
    2016 retraction notice: http://www.jci.org/articles/view/87345
    http://retractionwatch.com/2016/04/05/cancer-researcher-earns-9th-retraction-for-image-duplication/

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